موپرون

Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia. It is an antagonist for the D2 (Ki 0.7–1.9 nM), D3 (Ki 0.1–1 nM), and 5-HT2A (Ki 52 nM) receptors. It also has a high binding affinity for the sigma receptors.

Chemical data

Formula: C22H26FNO2
Molecular weight: 355.4 g/mol
IUPAC name: 1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)piperidin-1-yl]butan-1-one
SMILES: CC1=CC=C(C=C1)C2(CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F)O
InChIKey: AGAHNABIDCTLHW-UHFFFAOYSA-N
XLogP: 3
Polar surface area: 40.5 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: psychosis

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 355.195

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canonical SMILES: CC1=CC=C(C=C1)C2(CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F)O
chemical formula: C₂₂H₂₆FNO₂
Commons category: Moperone
defined daily dose: 20

Sources (3)

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via Wikidata sitelinks · CC0