NACA

Also known as NACA1, skNAC, HSD48, NAC-alpha, nascent polypeptide-associated complex alpha subunit, nascent polypeptide associated complex subunit alpha

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 7 inbound references to NACA, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 12 and Human proteins.

Vinony links it to 5 Wikipedia language editions.

Gene data

NACA

Name: nascent polypeptide associated complex subunit alpha
Type: protein-coding
Position: 56,712,305–56,731,628 (−)
Aliases: HSD48, NAC-alpha, NACA1, skNAC
Ensembl: ENSG00000196531
RefSeq RNA: NM_001113201.3, NM_001113202.2, NM_001113203.3, NM_001320193.2, NM_001320194.2
RefSeq protein: NP_001106672.1, NP_001106673.1, NP_001106674.2, NP_001307122.1, NP_001307123.1

This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016].