Structure via PubChem · Public domain (PubChem)
Naltrexon
Sign in to saveAlso known as (-)naltrexone, naltrexone HCl, ReVia®, N-Cyclopropylmethylnoroxymorphone, N-Cyclopropylmethyl-14-hydroxydihydromorphinone, 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one, 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, Naltrexone
chemische Verbindung
Key facts
- Drug.Verifiedfields
- verified
- Drug.Watchedfields
- verified
- Drug.verifiedrevid
- 464372546
- Drug.image
- Naltrexone_skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Naltrexone-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.tradename
- Revia, Vivitrol, Depade, others
- Drug.MedlinePlus
- a685041
- Drug.DailyMedID
- Naltrexone
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth, intramuscular, subcutaneous implant
- Drug.ATC_prefix
- N07
- Drug.ATC_suffix
- BB04
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
via Wikipedia infobox
Chemical data
- Formula
- C20H23NO4
- Molecular weight
- 341.4 g/mol
- IUPAC name
- (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
- SMILES
- C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O
- InChIKey
- DQCKKXVULJGBQN-XFWGSAIBSA-N
- XLogP
- 1.9
- Polar surface area
- 70 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1984
- Admin. routes
- oral, parenteral
- Indications
- gambling behaviour, opioid dependence, alcohol drinking, HIV infection
via ChEMBL · EBI
Research
12,325 papers- The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.Clinical rheumatology · 2014
- The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders.Pharmacotherapy · 2018
- Naltrexone at low doses (LDN) and its relevance to cancer therapy.Expert review of anticancer therapy · 2022
- Morphine/naltrexone.CNS drugs · 2010
- Naltrexone: A Pan-Addiction Treatment?CNS drugs · 2016
via PubMed
Wikidata facts
- Mass
- 341.162708
- Has use
- medication
Show 10 more facts
- Commons category
- Naltrexone
- chemical formula
- C₂₀H₂₃NO₄
- different from
- Low-dose naltrexone
- medical condition treated
- non-controlled substance abuse
- canonical SMILES
- C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O
- isomeric SMILES
- C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O
- World Health Organisation international non-proprietary name
- naltrexone
- defined daily dose
- 50
- subject has role
- opioid antagonist
- native label
- Naltrexone
via Wikidata · CC0
Article · Deutsch
Naltrexon ist ein verschreibungspflichtiger Arzneistoff und wie Naloxon ein reiner Opioidantagonist, der als kompetitiver Antagonist an allen Opioidrezeptoren wirkt.
Abstract from DBpedia / Wikipedia · CC BY-SA