نالتروکسان

Key facts

Drug.Verifiedfields

verified

Drug.Watchedfields

verified

Drug.verifiedrevid

464372546

Drug.image

Naltrexone_skeletal.svg

Drug.image_class

skin-invert-image

Drug.width

200

Drug.image2

Naltrexone-from-xtal-3D-bs-17.png

Drug.image_class2

bg-transparent

Drug.width2

250

Drug.tradename

Revia, Vivitrol, Depade, others

Drug.MedlinePlus

a685041

Drug.DailyMedID

Naltrexone

Drug.pregnancy_AU

B3

Drug.routes_of_administration

By mouth, intramuscular, subcutaneous implant

Drug.ATC_prefix

N07

Drug.ATC_suffix

BB04

Drug.legal_AU

S4

Drug.legal_BR

C1

via Wikipedia infobox

Chemical data

Formula

C20H23NO4

Molecular weight

341.4 g/mol

IUPAC name

(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

SMILES

C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O

InChIKey

DQCKKXVULJGBQN-XFWGSAIBSA-N

XLogP

1.9

Polar surface area

70 Ų

H-bond donors

2

H-bond acceptors

5

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1984

Admin. routes

oral, parenteral

Indications

gambling behaviour, opioid dependence, alcohol drinking, HIV infection

via ChEMBL · EBI

• The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.Clinical rheumatology · 2014
• The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders.Pharmacotherapy · 2018
• Naltrexone at low doses (LDN) and its relevance to cancer therapy.Expert review of anticancer therapy · 2022
• Morphine/naltrexone.CNS drugs · 2010
• Naltrexone: A Pan-Addiction Treatment?CNS drugs · 2016

via PubMed

Wikidata facts

Mass

341.162708

Has use

medication

via Wikidata · CC0