NANS

Also known as HEL-S-100, SAS, N-acetylneuraminate synthase, SEMDG, SEMDCG

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.

In the Vinony graph

Within Vinony's link graph, NANS is referenced by 5 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 9 and Human proteins.

Its subject is documented across 5 Wikipedia language editions.

Gene data

NANS

Name: N-acetylneuraminate synthase
Type: protein-coding
Aliases: HEL-S-100, SAS, SEMDCG, SEMDG

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

N-acetylneuraminate synthase

Symbol: NANS
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:98,056,637-98,084,394
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein NANS PDB 1wvo.png

Show 7 more facts

HomoloGene ID: 10343
genomic end: 100845357
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/54187
genomic start: 98056732
chromosome: human chromosome 9
cytogenetic location: 9q22.33

Sources (5)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.

Excerpted from Wikipedia’s “NANS” article, available under the CC BY-SA 4.0 licence.