NEU1
Sign in to saveAlso known as NANH, NEU, SIAL1, neuraminidase 1 (lysosomal sialidase), neuraminidase 1
Sialidase-1, is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.
Gene data
NEU1- Name
- neuraminidase 1
- Type
- protein-coding
- Aliases
- NANH, NEU, SIAL1
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
neuraminidase 1
- Symbol
- NEU1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_MCF_CTG1:3,199,729-3,204,976
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- C1-inhibitor.png
Show 5 more facts
- HomoloGene ID
- 375
- genomic start
- 31825436
- exact match
- identifiers.org/ncbigene/4758
- genomic end
- 31862905
- cytogenetic location
- 6p21.33
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Sialidase-1, is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.
== Function ==