NFASC

Name

neurofascin

Type

protein-coding

Position

204,828,651–205,022,822 (+)

Aliases

NEDCPMD, NF, NRCAML

Ensembl

ENSG00000163531

RefSeq RNA

NM_001005387.1, NM_001005388.3, NM_001005389.2, NM_001160331.2, NM_001160332.2

RefSeq protein

NP_001005388.2, NP_001005389.2, NP_001153803.1, NP_001153804.1, NP_001153805.1

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009].

via MyGene.info

Gene · Ensembl

neurofascin

Symbol

NFASC

Biotype

Protein coding

Organism

Homo sapiens

Location

1:204,828,651-205,022,822

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein NFASC PDB 3P3Y.png

via Wikidata · CC0