NFX1

Also known as NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.

Gene data

NFX1

Name: nuclear transcription factor, X-box binding 1
Type: protein-coding
Aliases: NFX2, TEG-42, Tex42

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

nuclear transcription factor, X-box binding 1

Symbol: NFX1
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:33,290,428-33,372,467
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 1875
genomic end: 33371157
exact match: identifiers.org/ncbigene/4799
genomic start: 33290512
cytogenetic location: 9p13.3

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Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.