Structure via PubChem · Public domain (PubChem)
nimorazole
Sign in to saveNimorazole (INN) is a nitroimidazole anti-infective. It is also being investigated for the treatment of head and neck cancer.
In the Vinony graph
Within Vinony's link graph, nimorazole is referenced by 44 other articles, and connects out to DDT, infection and (+)-catechin.
It is catalogued under topics including 4-Morpholinyl compounds, Antiprotozoal agents and Aromatase inhibitors.
Its subject is documented across 10 Wikipedia language editions.
Chemical data
- Formula
- C9H14N4O3
- Molecular weight
- 226.23 g/mol
- IUPAC name
- 4-[2-(5-nitroimidazol-1-yl)ethyl]morpholine
- SMILES
- C1COCCN1CCN2C=NC=C2[N+](=O)[O-]
- InChIKey
- MDJFHRLTPRPZLY-UHFFFAOYSA-N
- XLogP
- -0.4
- Polar surface area
- 76.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- head and neck squamous cell carcinoma, squamous cell carcinoma, amebiasis
via ChEMBL · EBI
Research
159 papers- Transcriptomic and epigenetic landscape of nimorazole-enhanced radiochemotherapy in head and neck cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2024
- Prognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts.Journal of translational medicine · 2023
- Randomized Phase 3 Trial of the Hypoxia Modifier Nimorazole Added to Radiation Therapy With Benefit Assessed in Hypoxic Head and Neck Cancers Determined Using a Gene Signature (NIMRAD).International journal of radiation oncology, biology, physics · 2024
- (15) N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields.Angewandte Chemie (International ed. in English) · 2021
- NIMRAD - a phase III trial to investigate the use of nimorazole hypoxia modification with intensity-modulated radiotherapy in head and neck cancer.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2014
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 226.107
Show 4 more facts
- canonical SMILES
- C1COCCN1CCN2C=NC=C2[N+](=O)[O-]
- chemical formula
- C₉H₁₄N₄O₃
- MCN code
- 2934.99.13
- Commons category
- Nimorazole
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Nimorazole (INN) is a nitroimidazole anti-infective. It is also being investigated for the treatment of head and neck cancer.
== References ==
Excerpted from Wikipedia’s “nimorazole” article, available under the CC BY-SA 4.0 licence.
Available in 10 languages
via Wikidata sitelinks · CC0