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GeneQ18053117· pop 5· linked from 25 articles

NLRC3

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Also known as CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system. It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells. NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.

Gene data

NLRC3
Name
NLR family CARD domain containing 3
Type
protein-coding
Position
3,538,090–3,577,403 (−)
Aliases
CLR16.2, NOD3
Ensembl
ENSG00000167984
RefSeq RNA
NM_178844.4, NR_075083.3, XM_047433769.1, XM_047433770.1, XM_047433771.1
RefSeq protein
NP_849172.2, XP_047289725.1, XP_047289726.1, XP_047289727.1, XP_054235777.1

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

Gene Ontology

Pathways

Innate Immune SystemImmune SystemSTING mediated induction of host immune responsesCytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN

via MyGene.info

Gene · Ensembl

NLR family CARD domain containing 3

Symbol
NLRC3
Biotype
Protein coding
Organism
Homo sapiens
Location
16:3,538,090-3,577,403
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
18720
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/197358
genomic end
3577403
genomic start
3589033
chromosome
human chromosome 16
cytogenetic location
16p13.3
expressed in
tonsil
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

1 sections
Contents
  • References

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system. It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells. NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.

==References==

Excerpted from Wikipedia’s “NLRC3” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0