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GeneQ18047439· pop 6· linked from 31 articles

NLRC5

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Also known as CLR16.1, NOD27, NOD4, NLR family, CARD domain containing 5, NLR family CARD domain containing 5

NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity. It also acts as an innate immune sensor to drive inflammatory cell death, PANoptosis. In humans, the NLRC5 protein is encoded by the NLRC5 gene. It has also been called NOD27, NOD4, and CLR16.1.

Gene data

NLRC5

Name: NLR family CARD domain containing 5
Type: protein-coding
Position: 56,989,485–57,084,238 (+)
Aliases: CLR16.1, NOD27, NOD4
Ensembl: ENSG00000140853
RefSeq RNA: NM_001330552.2, NM_001384950.1, NM_001384951.1, NM_001384952.1, NM_001384953.1
RefSeq protein: NP_001317481.1, NP_001371879.1, NP_001371880.1, NP_001371881.1, NP_001371882.1

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011].

Gene Ontology

Biological process

negative regulation of canonical NF-kappaB signal transduction negative regulation of canonical NF-kappaB signal transduction innate immune response innate immune response positive regulation of MHC class I biosynthetic process positive regulation of transcription by RNA polymerase II defense response to virus positive regulation of type II interferon-mediated signaling pathway

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding

Cellular component

nucleus nucleus nucleus cytoplasm cytoplasm cytosol cytosol cytosol

Pathways

Cytokine Signaling in Immune system Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 7/8 (TLR7/8) Cascade

via MyGene.info

Gene · Ensembl

NLR family CARD domain containing 5

Symbol: NLRC5
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:56,989,485-57,084,238
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 88935
exact match: identifiers.org/ncbigene/84166
genomic start: 57023397
genomic end: 57117443
cytogenetic location: 16q13

Sources (5)

via Wikidata · CC0

~2 min read

Article

3 sections

Contents

Structure
Function
References

NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity. It also acts as an innate immune sensor to drive inflammatory cell death, PANoptosis. In humans, the NLRC5 protein is encoded by the NLRC5 gene. It has also been called NOD27, NOD4, and CLR16.1.

== Structure ==

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Categories

Genes on human chromosome 16 LRR proteins NOD-like receptors