NLRC4
Sign in to saveAlso known as CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1
NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.
Gene data
NLRC4- Name
- NLR family CARD domain containing 4
- Type
- protein-coding
- Aliases
- AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
via MyGene.info
Gene · Ensembl
NLR family CARD domain containing 4
- Symbol
- NLRC4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:32,224,453-32,265,820
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 10924
- exact match
- identifiers.org/ncbigene/58484
- genomic end
- 32265732
- genomic start
- 32449522
- chromosome
- human chromosome 2
- cytogenetic location
- 2p22.3
- expressed in
- appendix
Sources (7)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Function
- Interactions
- Clinical significance
- References
- Further reading
NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.
== Structure ==
Excerpted from Wikipedia’s “NLRC4” article, available under the CC BY-SA 4.0 licence.