NLRP4
Sign in to saveAlso known as CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.
Gene data
NLRP4- Name
- NLR family pyrin domain containing 4
- Type
- protein-coding
- Aliases
- CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016].
via MyGene.info
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/147945
- HomoloGene ID
- 75315
- genomic start
- 55836540
- genomic end
- 55881855
- cytogenetic location
- 19q13.43
Sources (4)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.