Nucleotide binding oligomerization domain containing 2
Sign in to saveAlso known as Nod2 Signaling Adaptor Protein, caspase recruitment domain family, member 15, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2, NOD2, caspase recruitment domain protein 15, caspase recruitment domain-containing protein 15, NOD-like receptor C2, nucleotide-binding oligomerization domain-containing protein 2
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.
Protein · UniProt
Nucleotide-binding oligomerization domain-containing protein 2
- Gene
- NOD2
- Organism
- Homo sapiens (Human)
- Length
- 1,040 aa
- Molecular mass
- 115,283 Da
- Evidence
- 1: Evidence at protein level
Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity (PubMed:12514169, PubMed:12527755, PubMed:12626759, PubMed:15044951, PubMed:15998797, PubMed:27283905, PubMed:27748583, PubMed:31649195). Specifically activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan found in every bacterial peptidoglycan type (PubMed:12514169, PubMed:12527755, PubMed:12626759, PubMed:12871942, PubMed:15044951, PubMed:15198989, PubMed:15998797, PubMed:22857257, PubMed:23322906, PubMed:2…
Swiss-Prot (reviewed) · via UniProt
Research
1,259 papers- Endothelial nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome regulation in atherosclerosis.Cardiovascular research · 2024
- Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases.Seminars in arthritis and rheumatism · 2013
- Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease.Rheumatology (Oxford, England) · 2024
- Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis.Basic research in cardiology · 2020
- Reconstitution and structure of a plant NLR resistosome conferring immunity.Science (New York, N.Y.) · 2019
via PubMed
Clinical Trials
1 registered- NANOT_YET_RECRUITINGEvaluation of Nucleotide-Binding Oligomerization Domain-Containing Protein (NOD) 1 and NOD 2Medipol University · NCT07160894
Wikidata facts
- Instance of
- protein
- Has part
- CARD domain
- Image
- NOD2 protein.png
Show 3 more facts
- found in taxon
- Homo sapiens
- cell component
- cytosol
- exact match
- purl.uniprot.org/uniprot/Q9HC29
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.
NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.
Excerpted from Wikipedia’s “Nucleotide binding oligomerization domain containing 2” article, available under the CC BY-SA 4.0 licence.