Nucleotide binding oligomerization domain containing 2
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.
Research
1,259 papers- Endothelial nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome regulation in atherosclerosis.Cardiovascular research · 2024
- Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases.Seminars in arthritis and rheumatism · 2013
- Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease.Rheumatology (Oxford, England) · 2024
- Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis.Basic research in cardiology · 2020
- Reconstitution and structure of a plant NLR resistosome conferring immunity.Science (New York, N.Y.) · 2019
via PubMed
Article
7 sectionsContents
- Structure
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.
NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.