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GeneQ18048545· pop 6· linked from 34 articles

NLRP12

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Also known as CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2, NLR family, pyrin domain containing 12

Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or NALP12) is a protein that in humans is encoded by the NLRP12 gene.

Gene data

NLRP12
Name
NLR family pyrin domain containing 12
Type
protein-coding
Position
53,792,139–53,824,403 (−)
Aliases
CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
Ensembl
ENSG00000142405
RefSeq RNA
NM_001277126.2, NM_001277129.1, NM_033297.2, NM_144687.4, XM_011527479.2
RefSeq protein
NP_001264055.1, NP_001264058.1, NP_653288.1, XP_011525781.1, XP_011525782.1

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].

Gene Ontology

Pathways

NOD-like receptor signaling pathway - Homo sapiens (human)DiseaseInfectious diseaseSARS-CoV InfectionsSARS-CoV-2 InfectionSARS-CoV-2 activates/modulates innate and adaptive immune responsesSARS-CoV-2-host interactionsViral Infection PathwaysNucleotide-binding Oligomerization Domain (NOD) pathway

via MyGene.info

Gene · Ensembl

NLR family pyrin domain containing 12

Symbol
NLRP12
Biotype
Protein coding
Organism
Homo sapiens
Location
19:53,792,139-53,824,403
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

4 sections
Contents
  • NLRP structure
  • NLRP12 function and pathology
  • References
  • Further reading

Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or NALP12) is a protein that in humans is encoded by the NLRP12 gene.

== NLRP structure == NLRPs, or NALPs, are cytoplasmic innate immune sensors that form a subfamily within the larger CATERPILLER protein family. Most short NLRP proteins, including NLRP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).

Excerpted from Wikipedia’s “NLRP12” article, available under the CC BY-SA 4.0 licence.

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