NMT1

Also known as AW536594, NMT, N-myristoyltransferase 1

protein-coding gene in the species Homo sapiens

Gene data

NMT1

Name: N-myristoyltransferase 1
Type: protein-coding
Position: 44,957,992–45,109,016 (+)
Aliases: HsNMT1, NMT
Ensembl: ENSG00000136448
RefSeq RNA: NM_021079.5
RefSeq protein: NP_066565.1

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008].