PACRG
Sign in to saveAlso known as GLUP, HAK005771, PARK2CRG, PARK2 co-regulated, PARK2 coregulated, parkin coregulated, PACRG2.1
Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.
Gene data
PACRG- Name
- parkin coregulated
- Type
- protein-coding
- Aliases
- BUG21, GLUP, HAK005771, PACRG2.1, PARK2CRG, pf12
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 16212
- genomic start
- 162727132
- exact match
- identifiers.org/ncbigene/135138
- genomic end
- 163315500
- cytogenetic location
- 6q26
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Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.