PACRG
Sign in to saveAlso known as GLUP, HAK005771, PARK2CRG, PARK2 co-regulated, PARK2 coregulated, parkin coregulated, PACRG2.1
Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.
In the Vinony graph
Within Vinony's link graph, PACRG is referenced by 2 other articles, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 6.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PACRG- Name
- parkin coregulated
- Type
- protein-coding
- Position
- 162,727,095–163,315,535 (+)
- Aliases
- BUG21, GLUP, HAK005771, PACRG2.1, PARK2CRG, pf12
- Ensembl
- ENSG00000112530
- RefSeq RNA
- NM_001080378.2, NM_001080379.2, NM_152410.3, XM_005266825.6, XM_005266826.6
- RefSeq protein
- NP_001073847.1, NP_001073848.1, NP_689623.2, XP_005266882.1, XP_005266883.1
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
parkin coregulated
- Symbol
- PACRG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:162,727,095-163,315,535
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 16212
- genomic start
- 162727132
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/135138
- genomic end
- 163315500
- chromosome
- human chromosome 6
- cytogenetic location
- 6q26
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Excerpted from Wikipedia’s “PACRG” article, available under the CC BY-SA 4.0 licence.