CLDN8
Sign in to saveAlso known as HEL-S-79, claudin 8
Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins.
In the Vinony graph
Within Vinony's link graph, CLDN8 is referenced by 3 other articles, and connects out to PubMed, human chromosome 21 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 21.
Its subject is documented across 5 Wikipedia language editions.
Gene data
CLDN8- Name
- claudin 8
- Type
- protein-coding
- Position
- 30,214,006–30,216,097 (−)
- Aliases
- HEL-S-79
- Ensembl
- ENSG00000156284
- RefSeq RNA
- NM_012132.3, NM_199328.3
- RefSeq protein
- NP_955360.1
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
claudin 8
- Symbol
- CLDN8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 21:30,214,006-30,216,097
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 8117
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9073
- genomic end
- 30216097
- genomic start
- 31586324
- chromosome
- human chromosome 21
- cytogenetic location
- 21q22.11
- expressed in
- seminal vesicula
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins.
==References==
Excerpted from Wikipedia’s “CLDN8” article, available under the CC BY-SA 4.0 licence.