CLDN7
Sign in to saveAlso known as CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.
Gene data
CLDN7- Name
- claudin 7
- Type
- protein-coding
- Aliases
- CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9649
- exact match
- identifiers.org/ncbigene/1366
- genomic end
- 7167302
- genomic start
- 7163222
- cytogenetic location
- 17p13.1
Sources (3)
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Article
3 sectionsContents
- References
- External links
- Further reading
Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.
Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM]