CLDN12

Name

claudin 12

Type

protein-coding

Position

90,383,721–90,513,402 (+)

Ensembl

ENSG00000157224

RefSeq RNA

NM_001185072.3, NM_001185073.3, NM_012129.5

RefSeq protein

NP_001172001.1, NP_001172002.1, NP_036261.1

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011].

via MyGene.info

Gene · Ensembl

claudin 12

Symbol

CLDN12

Biotype

Protein coding

Organism

Homo sapiens

Location

7:90,383,721-90,513,402

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0