PALS1
Sign in to saveAlso known as membrane palmitoylated protein 5, protein associated with LIN7 1, MAGUK p55 family member, MPP5, protein associated with LIN7 1, MAGUK family member
MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene. Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of addi
In the Vinony graph
Within Vinony's link graph, PALS1 is referenced by 3 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PALS1- Name
- protein associated with LIN7 1, MAGUK p55 family member
- Type
- protein-coding
- Position
- 67,240,713–67,336,061 (+)
- Aliases
- MPP5
- Ensembl
- ENSG00000072415
- RefSeq RNA
- NM_001256550.2, NM_022474.4, XM_005268003.2, XM_011537086.3, XM_011537087.3
- RefSeq protein
- NP_001243479.1, NP_071919.2, XP_005268060.1, XP_011535388.1, XP_011535389.1
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein associated with LIN7 1, MAGUK p55 family member
- Symbol
- PALS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:67,240,713-67,336,061
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MPP5 PDB 1va8.png
Show 7 more facts
- HomoloGene ID
- 9512
- genomic start
- 67240713
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/64398
- genomic end
- 67336061
- chromosome
- human chromosome 14
- cytogenetic location
- 14q23.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene. Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM]
==Interactions== MPP5 has been shown to interact with INADL and FAM71D.
Excerpted from Wikipedia’s “PALS1” article, available under the CC BY-SA 4.0 licence.