TNK2

Also known as ACK, ACK-1, ACK1, p21cdc42Hs, tyrosine kinase non receptor 2

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound

Gene data

TNK2

Name: tyrosine kinase non receptor 2
Type: protein-coding
Position: 195,863,364–195,911,945 (−)
Aliases: ACK, ACK-1, ACK1, p21cdc42Hs
Ensembl: ENSG00000061938
RefSeq RNA: NM_001010938.2, NM_001308046.2, NM_001382271.1, NM_001382272.1, NM_001382273.1
RefSeq protein: NP_001010938.2, NP_001294975.1, NP_001369200.1, NP_001369201.1, NP_001369202.1

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].

Pathways

Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by LTK Focal Adhesion Oxidative Damage EGF-EGFR signaling pathway G13 Signaling Pathway

via MyGene.info

Wikidata facts

Image: Protein TNK2 PDB 1cf4.png

Show 5 more facts

HomoloGene ID: 4224
exact match: identifiers.org/ncbigene/10188
genomic start: 195863364
genomic end: 195911945
cytogenetic location: 3q29

Sources (3)

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Contents

Interactions
Clinical relevance
ACK1 inhibitors
Further reading
External links

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.

TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.