PCDHA9
Sign in to saveAlso known as PCDH-ALPHA9, protocadherin alpha 9
Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene.
In the Vinony graph
Within Vinony's link graph, PCDHA9 is referenced by 2 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 5.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PCDHA9- Name
- protocadherin alpha 9
- Type
- protein-coding
- Position
- 140,847,772–141,012,351 (+)
- Aliases
- PCDH-ALPHA9
- Ensembl
- ENSG00000291657
- RefSeq RNA
- NM_014005.5, NM_031857.2
- RefSeq protein
- NP_054724.1, NP_114063.1
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
protocadherin alpha 9
- Symbol
- PCDHA9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:140,847,772-141,012,351
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 129614
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9752
- chromosome
- human chromosome 5
- genomic start
- 140847772
- genomic end
- 141012347
- cytogenetic location
- 5q31.3
- expressed in
- ganglionic eminence
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene.
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome 5 that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Excerpted from Wikipedia’s “PCDHA9” article, available under the CC BY-SA 4.0 licence.