PCDHA4
Sign in to saveAlso known as CNR1, CNRN1, CRNR1, PCDH-ALPHA4, protocadherin alpha 4
Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.
In the Vinony graph
Within Vinony's link graph, PCDHA4 is referenced by 3 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 5.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PCDHA4- Name
- protocadherin alpha 4
- Type
- protein-coding
- Position
- 140,807,037–141,012,347 (+)
- Aliases
- CNR1, CNRN1, CRNR1, PCDH-ALPHA4
- Ensembl
- ENSG00000291652
- RefSeq RNA
- NM_018907.4, NM_031500.3
- RefSeq protein
- NP_061730.1, NP_113688.1
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
protocadherin alpha 4
- Symbol
- PCDHA4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:140,807,037-141,012,347
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PCDHA4 PDB 1wuz.png
Show 7 more facts
- HomoloGene ID
- 130626
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/56144
- chromosome
- human chromosome 5
- genomic start
- 140186659
- genomic end
- 141012347
- cytogenetic location
- 5q31.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Excerpted from Wikipedia’s “PCDHA4” article, available under the CC BY-SA 4.0 licence.