PCDHA4
Sign in to saveAlso known as CNR1, CNRN1, CRNR1, PCDH-ALPHA4, protocadherin alpha 4
Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.
Gene data
PCDHA4- Name
- protocadherin alpha 4
- Type
- protein-coding
- Aliases
- CNR1, CNRN1, CRNR1, PCDH-ALPHA4
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- Protein PCDHA4 PDB 1wuz.png
Show 5 more facts
- HomoloGene ID
- 130626
- exact match
- identifiers.org/ncbigene/56144
- genomic start
- 140186659
- genomic end
- 141012347
- cytogenetic location
- 5q31.3
Sources (3)
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Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.