pempidine

Pempidine is a nicotinic antagonist drug, first reported in 1958 by two research groups working independently, and introduced as an oral treatment for hypertension.

Chemical data

Formula: C10H21N
Molecular weight: 155.28 g/mol
IUPAC name: 1,2,2,6,6-pentamethylpiperidine

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Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

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Research

212 papers

Pempidine for Hypertension.British medical journal · 1961
Congeners of pempidine with high ganglion-blocking activity.Nature · 1959
Absorption, metabolism and elimination of pempidine in the rat.British journal of pharmacology and chemotherapy · 1959
Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine.The Journal of pharmacology and experimental therapeutics · 1990
ACTIONS OF MECAMYLAMINE, DIMECAMINE, PEMPIDINE AND THEIR TWO QUATERNARY METHO-SALTS AT THE NEUROMUSCULAR JUNCTION.British journal of pharmacology and chemotherapy · 1964

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Wikidata facts

Mass: 155.167

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chemical formula: C₁₀H₂₁N
canonical SMILES: CC1(CCCC(N1C)(C)C)C
Commons category: Pempidine

Sources (2)

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Article

5 sections

Contents

Pharmacology
Toxicology
Chemistry
References
External links

Pempidine is a nicotinic antagonist drug, first reported in 1958 by two research groups working independently, and introduced as an oral treatment for hypertension.

==Pharmacology== Reports on the "classical" pharmacology of pempidine have been published. The Spinks group, at ICI, compared pempidine, its N-ethyl analogue, and mecamylamine in considerable detail, with additional data related to several structurally simpler compounds.