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Structure via PubChem · Public domain (PubChem)
pentolinium
Sign in to saveAlso known as Pentolonum, Pentolonium, Pentolineum
Pentolinium, also known as pentapyrrolidinium, is a ganglionic blocking agent which acts as a nicotinic acetylcholine receptor antagonist. Formulated as the pentolinium tartrate salt, it was marketed under the trade name Ansolysen. It can be used as an antihypertensive drug during surgery or to control hypertensive crises. It works by binding to the acetylcholine receptor of adrenergic nerves and thereby inhibiting the release of noradrenaline and adrenaline. Blocking this receptor leads to smooth muscle relaxation and vasodilation.
Chemical data
- Formula
- C15H32N2+2
- Molecular weight
- 240.43 g/mol
- IUPAC name
- 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
- SMILES
- C[N+]1(CCCC1)CCCCC[N+]2(CCCC2)C
- InChIKey
- XSBSKEQEUFOSDD-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 0 Ų
- H-bond donors
- 0
- H-bond acceptors
- 0
- Formal charge
- 2
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- parenteral
via ChEMBL · EBI
Wikidata facts
- Subclass of
- ganglionic blocker
- Mass
- 240.25545186417997
- Has use
- medication
Show 3 more facts
- canonical SMILES
- C[N+]1(CCCC1)CCCCC[N+]2(CCCC2)C
- Commons category
- Pentolinium
- chemical formula
- C₁₅H₃₂N₂²⁺
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Route of administration and dose
- Use
- History
- References
- External links
Pentolinium, also known as pentapyrrolidinium, is a ganglionic blocking agent which acts as a nicotinic acetylcholine receptor antagonist. Formulated as the pentolinium tartrate salt, it was marketed under the trade name Ansolysen. It can be used as an antihypertensive drug during surgery or to control hypertensive crises. It works by binding to the acetylcholine receptor of adrenergic nerves and thereby inhibiting the release of noradrenaline and adrenaline. Blocking this receptor leads to smooth muscle relaxation and vasodilation.
==Route of administration and dose == Pentolinium can be given orally (20mg three times a day), injected intramuscularly, or administered intravenously.
Excerpted from Wikipedia’s “pentolinium” article, available under the CC BY-SA 4.0 licence.