pipotiazine

Pipotiazine (Piportil), also known as pipothiazine, is a typical antipsychotic of the phenothiazine class used in the United Kingdom and other countries for the treatment of schizophrenia. Its properties are similar to those of chlorpromazine. A 2004 systematic review investigated its efficacy for people with schizophrenia: {| class="wikitable" |+ Pipotiazine palmitate compared to oral antipsychotics for schizophrenia |- ! Summary |- |Although well-conducted and reported randomized trials are still needed to fully inform practice (no trial data exists reporting hospital and services outcomes, quality of life, satisfaction with care and economics) pipotiazine palmitate is a viable choice for both clinician and person with schizophrenia. |- | style="padding:0;" | {| class="wikitable collapsible collapsed" style="width:100%;" |- ! scope="col" style="text-align: left;"| Outcome ! scope="col" style="text-align: left;"| Findings in words ! scope="col" style="text-align: left;"| Findings in numbers ! scope="col" style="text-align: left;"| Quality of evidence |- ! colspan="4" style="text-align: left;"| Global outcomes |- | No important clinical responseFollow-up: by 3 week) || There is no clear difference between people given pipotiazine palmitate and those receiving oral antipsychotics. These findings are based on data of low quality. || RR 2.57 (0.76 to 8.63) || Low |- | Leaving the study earlyFollow-up: up to 5 weeks || Pipotiazine palmitate may increase the chance of leaving the study early but the difference between people given pipotiazine palmitate and those receiving oral antipsychotics is not clear. These findings are based on data of low quality. || RR 3.85 (0.46 to 32.22) || Low |- ! colspan="4" style="text-align: left;"| Mental state |- | RelapseFollow-up: by 18 months) || Pipotiazine palmitate has not more - or less - effect on risk of relapse than oral antipsychotics. These findings are based on data of low quality. || RR 1.55 (0.76 to 3.18) || Low |- ! colspan="4" style="text-align: left;"| Adverse effects |- | Tardive dyskinesia || Oral antipsychotic drugs and pipotiazine palmitate carry similar risks of this problematic movement disorder. These findings are based on data of low quality. || RR 1.03 (0.22 to 4.92) || Low |- | Dystonia || Pipotiazine palmitate may slightly reduce the chance of experiencing this movement disorder but there is no clear difference between people given pipotiazine palmitate and those receiving oral antipsychotics. These findings are based on data of low quality. || RR 0.32 (0.04 to 2.89) || Low |- |} |}

==Medical uses== Pipotiazine palmitate is used to treat schizophrenia.