Structure via PubChem · Public domain (PubChem)
zicronapine
Sign in to saveZicronapine ( , previously known as Lu 31-130) is an atypical antipsychotic medication formerly under development by H. Lundbeck A/S. In phase II studies zicronapine showed statistically significant separation from placebo and convincing efficacy and safety data when compared to olanzapine.
Chemical data
- Formula
- C22H27ClN2
- Molecular weight
- 354.9 g/mol
- IUPAC name
- 4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine
- SMILES
- CC1(CN(CCN1C)[C@@H]2C[C@H](C3=C2C=C(C=C3)Cl)C4=CC=CC=C4)C
- InChIKey
- BYPMJBXPNZMNQD-PZJWPPBQSA-N
- XLogP
- 4.7
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- schizophrenia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 354.186
Show 4 more facts
- chemical formula
- C₂₂H₂₇ClN₂
- canonical SMILES
- CC1(CN(CCN1C)C2CC(C3=C2C=C(C=C3)Cl)C4=CC=CC=C4)C
- isomeric SMILES
- CC1(CN(CCN1C)[C@@H]2C[C@H](C3=C2C=C(C=C3)Cl)C4=CC=CC=C4)C
- Commons category
- Zicronapine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Zicronapine ( , previously known as Lu 31-130) is an atypical antipsychotic medication formerly under development by H. Lundbeck A/S. In phase II studies zicronapine showed statistically significant separation from placebo and convincing efficacy and safety data when compared to olanzapine.
Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors.
Excerpted from Wikipedia’s “zicronapine” article, available under the CC BY-SA 4.0 licence.