PLA2G2A

Name

phospholipase A2 group IIA

Type

protein-coding

Position

19,975,431–19,980,462 (−)

Aliases

MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2

Ensembl

ENSG00000188257

RefSeq RNA

NM_000300.4, NM_001161727.2, NM_001161728.2, NM_001161729.1, NM_001395463.1

RefSeq protein

NP_000291.1, NP_001155199.1, NP_001155200.1, NP_001155201.1, NP_001382392.1

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009].

via MyGene.info

Wikidata facts

Image

Protein PLA2G2A PDB 1ayp.png

via Wikidata · CC0