Pleconaril

Chemical data

Formula

C18H18F3N3O3

Molecular weight

381.3 g/mol

IUPAC name

3-[3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole

SMILES

CC1=CC(=CC(=C1OCCCC2=CC(=NO2)C)C)C3=NOC(=N3)C(F)(F)F

InChIKey

KQOXLKOJHVFTRN-UHFFFAOYSA-N

XLogP

4.6

Polar surface area

74.2 Ų

H-bond donors

0

H-bond acceptors

9

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 2

Molecule type

Small molecule

Indications

viral disease, type 1 diabetes mellitus, Enterovirus infectious disease

via ChEMBL · EBI

• The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants.Antiviral research · 2024
• Pleconaril, a novel antipicornaviral agent.Pharmacotherapy · 2003
• Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial.Nature medicine · 2023
• Pleconaril Sanofi Synthélabo/ViroPharma.Current opinion in investigational drugs (London, England : 2000) · 2000
• Clinical characteristics of severe neonatal enterovirus infection: a systematic review.BMC pediatrics · 2021

via PubMed

Wikidata facts

Mass

381.13

via Wikidata · CC0