Structure via PubChem · Public domain (PubChem)
Chemical data
- Formula
- C18H18F3N3O3
- Molecular weight
- 381.3 g/mol
- IUPAC name
- 3-[3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
- SMILES
- CC1=CC(=CC(=C1OCCCC2=CC(=NO2)C)C)C3=NOC(=N3)C(F)(F)F
- InChIKey
- KQOXLKOJHVFTRN-UHFFFAOYSA-N
- XLogP
- 4.6
- Polar surface area
- 74.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- viral disease, type 1 diabetes mellitus, Enterovirus infectious disease
via ChEMBL · EBI
Research
208 papers- The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants.Antiviral research · 2024
- Pleconaril, a novel antipicornaviral agent.Pharmacotherapy · 2003
- Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial.Nature medicine · 2023
- Pleconaril Sanofi Synthélabo/ViroPharma.Current opinion in investigational drugs (London, England : 2000) · 2000
- Clinical characteristics of severe neonatal enterovirus infection: a systematic review.BMC pediatrics · 2021
via PubMed
Wikidata facts
- Mass
- 381.13
Show 4 more facts
- found in taxon
- Isatis tinctoria
- Commons category
- Pleconaril
- chemical formula
- C₁₈H₁₈F₃N₃O₃
- canonical SMILES
- CC1=CC(=CC(=C1OCCCC2=CC(=NO2)C)C)C3=NOC(=N3)C(F)(F)F
Sources (2)
via Wikidata · CC0
Article · Italiano
Il pleconaril è un farmaco antivirale sviluppato dalla Merck & Co. per la prevenzione dell'esacerbazione dell'asma e per prevenire i sintomi del raffreddore in soggetti asmatici sensibili al picornaviridae.
Abstract from DBpedia / Wikipedia · CC BY-SA