PLEK2

Also known as pleckstrin 2

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.

In the Vinony graph

Within Vinony's link graph, PLEK2 is referenced by 3 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Its subject is documented across 6 Wikipedia language editions.

Gene data

PLEK2

Name: pleckstrin 2
Type: protein-coding
Position: 67,385,652–67,412,236 (−)
Ensembl: ENSG00000100558
RefSeq RNA: NM_016445.3, XM_047431262.1, XM_047431263.1, XM_054375851.1, XM_054375852.1
RefSeq protein: NP_057529.1, XP_047287218.1, XP_047287219.1, XP_054231826.1, XP_054231827.1

The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015].

Gene Ontology

Biological process

actin cytoskeleton organization actin cytoskeleton organization intracellular signal transduction erythrocyte enucleation positive regulation of plasma membrane bounded cell projection assembly

Molecular function

phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-3,5-bisphosphate binding

Cellular component

cytoskeleton plasma membrane plasma membrane membrane lamellipodium membrane

via MyGene.info

Gene · Ensembl

pleckstrin 2

Symbol: PLEK2
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:67,385,652-67,412,236
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein PLEK2 PDB 1v3f.png

Show 7 more facts

HomoloGene ID: 8447
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/26499
genomic end: 67412167
genomic start: 67386984
chromosome: human chromosome 14
cytogenetic location: 14q23.3-q24.1

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.

==References==

Excerpted from Wikipedia’s “PLEK2” article, available under the CC BY-SA 4.0 licence.