SPHK2
Sign in to saveAlso known as SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.
In the Vinony graph
Vinony's link graph records 6 inbound references to SPHK2, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
It is catalogued under topics including EC 2.7.1 and Genes on human chromosome 19.
Vinony links it to 6 Wikipedia language editions.
Gene data
SPHK2- Name
- sphingosine kinase 2
- Type
- protein-coding
- Position
- 48,619,291–48,630,717 (+)
- Aliases
- SK 2, SK-2, SPK 2, SPK-2
- Ensembl
- ENSG00000063176
- RefSeq RNA
- NM_001204158.3, NM_001204159.3, NM_001204160.3, NM_001243876.2, NM_020126.5
- RefSeq protein
- NP_001191087.1, NP_001191088.1, NP_001191089.1, NP_001230805.1, NP_064511.2
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
sphingosine kinase 2
- Symbol
- SPHK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:48,619,291-48,630,717
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 32456
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/56848
- genomic end
- 49133974
- genomic start
- 49122548
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.33
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Inhibitors
- References
- Further reading
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Excerpted from Wikipedia’s “SPHK2” article, available under the CC BY-SA 4.0 licence.