Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.
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Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).