SPHK2
Sign in to saveAlso known as SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.
Gene data
SPHK2- Name
- sphingosine kinase 2
- Type
- protein-coding
- Position
- 48,619,291–48,630,717 (+)
- Aliases
- SK 2, SK-2, SPK 2, SPK-2
- Ensembl
- ENSG00000063176
- RefSeq RNA
- NM_001204158.3, NM_001204159.3, NM_001204160.3, NM_001243876.2, NM_020126.5
- RefSeq protein
- NP_001191087.1, NP_001191088.1, NP_001191089.1, NP_001230805.1, NP_064511.2
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 32456
- exact match
- identifiers.org/ncbigene/56848
- genomic end
- 49133974
- genomic start
- 49122548
- cytogenetic location
- 19q13.33
Sources (3)
via Wikidata · CC0
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Article
3 sectionsContents
- Inhibitors
- References
- Further reading
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.