PMM1

Also known as Sec53, phosphomannomutase 1, PMMH-22, PMM 1

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.

Gene data

PMM1

Name: phosphomannomutase 1
Type: protein-coding
Position: 41,576,896–41,595,275 (−)
Aliases: PMM 1, PMMH-22, Sec53
Ensembl: ENSG00000100417
RefSeq RNA: NM_002676.3, XM_005261638.5, XM_011530229.3, XM_011530230.3, XM_011530231.4
RefSeq protein: NP_002667.2, XP_005261695.1, XP_011528531.1, XP_011528532.1, XP_011528533.1

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

mannose metabolic process mannose metabolic process mannose metabolic process mannose metabolic process protein N-linked glycosylation GDP-mannose biosynthetic process GDP-mannose biosynthetic process

Molecular function

phosphomannomutase activity phosphomannomutase activity phosphomannomutase activity phosphomannomutase activity phosphomannomutase activity protein binding

Cellular component

cytoplasm cytosol cytosol cytosol neuronal cell body

Pathways

Fructose and mannose metabolism - Homo sapiens (human)Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)Metabolism of proteins Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Asparagine N-linked glycosylation Synthesis of GDP-mannose Synthesis of substrates in N-glycan biosythesis Post-translational protein modification

via MyGene.info

Gene · Ensembl

phosphomannomutase 1

Symbol: PMM1
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:41,576,886-41,595,275
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PMM1 PDB 2fuc.png

Show 5 more facts

HomoloGene ID: 90898
exact match: identifiers.org/ncbigene/5372
genomic end: 41589871
genomic start: 41576900
cytogenetic location: 22q13.2

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Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of Glycosylphosphatidylinositol (GPI) anchored proteins.