Structure via PubChem · Public domain (PubChem)
pozanicline
Sign in to savePozanicline (INN, codenamed ABT-089) is a drug developed by Abbott, that has nootropic and neuroprotective effects. Animal studies suggested it useful for the treatment of ADHD and subsequent human trials have shown ABT-089 to be effective for this application. It binds with high affinity subtype-selective to the α4β2 nicotinic acetylcholine receptors and has partial agonism to the α6β2 subtype, but not the α7 and α3β4 subtypes familiar to nicotine. It has particularly low tendency to cause side effects compared to other drugs in the class.
Chemical data
- Formula
- C11H16N2O
- Molecular weight
- 192.26 g/mol
- IUPAC name
- 2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
- SMILES
- CC1=C(C=CC=N1)OC[C@@H]2CCCN2
- InChIKey
- YRVIKLBSVVNSHF-JTQLQIEISA-N
- XLogP
- 1.3
- Polar surface area
- 34.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- attention deficit hyperactivity disorder, nicotine dependence, Alzheimer disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 192.126263
Show 5 more facts
- Commons category
- Pozanicline
- chemical formula
- C₁₁H₁₆N₂O
- isomeric SMILES
- CC1=C(C=CC=N1)OC[C@@H]2CCCN2
- canonical SMILES
- CC1=C(C=CC=N1)OCC2CCCN2
- subject has role
- nootropic
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 448113772 | IUPAC_name = 2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine | image = Pozanicline.svg | image_class = skin-invert-image | width = 175
| tradename = | routes_of_administration =
Excerpted from Wikipedia’s “pozanicline” article, available under the CC BY-SA 4.0 licence.