Also known as periplakin
Periplakin is a protein that in humans is encoded by the PPL gene.
In the Vinony graph
Vinony's link graph records 276 inbound references to PPL, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.
It sits within the topics Genes on human chromosome 16 and Plakins.
Vinony links it to 5 Wikipedia language editions.
Gene data
PPL- Name
- periplakin
- Type
- protein-coding
- Position
- 4,879,449–4,960,741 (−)
- Ensembl
- ENSG00000118898
- RefSeq RNA
- NM_002705.5, XM_006720902.5, XM_017023374.3, XM_017023375.3, XM_054380583.1
- RefSeq protein
- NP_002696.4, XP_006720965.1, XP_016878863.1, XP_016878864.1, XP_054236558.1
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
periplakin
- Symbol
- PPL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:4,879,449-4,960,741
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2026
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5493
- genomic end
- 5010742
- genomic start
- 4932508
- chromosome
- human chromosome 16
- cytogenetic location
- 16p13.3
- expressed in
- Human penis
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Periplakin is a protein that in humans is encoded by the PPL gene.
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
Excerpted from Wikipedia’s “PPL” article, available under the CC BY-SA 4.0 licence.