پردنیزون

Also known as Lodotra®, Sterapred®, 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione, 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione, 1,2-Dehydrocortisone, Dehydrocortisone, prednison, Prednisone

ترکیب شیمیایی

Key facts

Drug.class: Glucocorticoid
Drug.ATC_prefix: A07
Drug.ATC_suffix: EA03
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.bioavailability: 70%
Drug.metabolism: prednisolone (liver)
Drug.elimination_half life: 3 to 4 hours in adults. 1 to 2 hours in children
Drug.excretion: Kidney
Drug.CAS_number: 53-03-2
Drug.PubChem: 5865
Drug.IUPHAR_ligand: 7096
Drug.DrugBank: DB00635
Drug.ChemSpiderID: 5656
Drug.UNII: VB0R961HZT
Drug.KEGG: C07370
Drug.ChEBI: 8382

via Wikipedia infobox

Chemical data

Formula: C21H26O5
Molecular weight: 358.4 g/mol
IUPAC name: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
SMILES: C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C
InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
XLogP: 1.5
Polar surface area: 91.7 Å²
H-bond donors: 2
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1955
Admin. routes: oral
Indications: Nasal Cavity Polyp, pulmonary sarcoidosis, rheumatoid arthritis, Sciatica

via ChEMBL · EBI

Research

61,377 papers

[Prednisone].Nederlands tijdschrift voor geneeskunde · 1956
Prednisone.IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans · 1981
[Abiraterone plus prednisone in patients with newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC)].Aktuelle Urologie · 2019
Prednisone and predinisolone.The Practitioner · 1958
Clinical pharmacokinetics of prednisone and prednisolone.Clinical pharmacokinetics · 1979

via PubMed

Wikidata facts

Subclass of: steroid
Mass: 358.178
Has use: medication

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medical condition treated: giant cell arteritis
chemical formula: C₂₁H₂₆O₅
Commons category: Prednisone
isomeric SMILES: C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C
canonical SMILES: CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
World Health Organisation international non-proprietary name: prednisone
subject has role: glucocorticoid
defined daily dose: 10
different from: prednisolone
melting point: 237
significant drug interaction: hydrochlorothiazide
has characteristic: bitterness
stylized name: predniSONE

Sources (5)

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Gallery (5)

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via Wikidata sitelinks · CC0