催乳素受体
Sign in to saveAlso known as HPRL, RI-PRLR, prolactin receptor, MFAB, hPRLrI, Prolactin receptor, PRLR, IPR033230
位於5號人類染色體的基因
Gene data
PRLR- Name
- prolactin receptor
- Type
- protein-coding
- Position
- 35,048,756–35,230,678 (−)
- Aliases
- HPRL, MFAB, RI-PRLR, hPRLrI
- Ensembl
- ENSG00000113494
- RefSeq RNA
- NM_000949.7, NM_001204314.2, NM_001204315.1, NM_001204316.1, NM_001204317.1
- RefSeq protein
- NP_000940.1, NP_001191243.1, NP_001191244.1, NP_001191245.1, NP_001191246.1
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
prolactin receptor
- Symbol
- PRLR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:35,048,756-35,230,678
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Subclass of
- cytokine receptor
Show 10 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 733
- exact match
- identifiers.org/ncbigene/5618
- genomic end
- 35230487
- genomic start
- 35048861
- chromosome
- human chromosome 5
- cytogenetic location
- 5p13.2
- genetic association
- hyperprolactinemia
- Commons category
- Prolactin receptor
via Wikidata · CC0
Article · 中文
催乳素受体（英語：prolactin receptor）由染色体5p13-14区段的基因编码，作为一种跨膜受体与催乳素相互作用。 它包括一个胞外区以结合催乳素，一个跨膜区，以及一个胞内区域。 该受体属于细胞因子受体，其第二信使信号通过JAK-STAT信号通路、JAK-RUSH信号通路、Ras-Raf-MAPK和PI-3K途径级联放大。 不同组织的催乳素受体可能会有所变化。
Abstract from DBpedia / Wikipedia · CC BY-SA