Structure via PubChem · Public domain (PubChem)
پروبنیسید
Sign in to saveAlso known as Probalan®, p-(Dipropylsulfamoyl)benzoic acid, 4-((Dipropylamino)sulfonyl)benzoic acid, Probenecid Acid, Probenecide, 4-(Di-N-propylsulfamoyl)benzoesaeure, Probenecid, Probenecida
Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia.
Key facts
- Drug.verifiedrevid
- 459812016
- Drug.IUPAC_name
- 4-(dipropylsulfamoyl)benzoic acid
- Drug.image
- Probenecid.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Probenecid ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Probalan
- Drug.MedlinePlus
- a682395
- Drug.legal_status
- Rx only
- Drug.routes_of_administration
- By mouth
- Drug.protein_bound
- 75-95%
- Drug.elimination_half life
- 2-6 hours (dose: 0.5-1 g)
- Drug.excretion
- kidney (77-88%)
- Drug.CAS_number
- 57-66-9
- Drug.ATC_prefix
- M04
- Drug.ATC_suffix
- AB01
via Wikipedia infobox
Chemical data
- Formula
- C13H19NO4S
- Molecular weight
- 285.36 g/mol
- IUPAC name
- 4-(dipropylsulfamoyl)benzoic acid
- SMILES
- CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
- InChIKey
- DBABZHXKTCFAPX-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 83.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1951
- Admin. routes
- oral
- Indications
- gout, infection, neoplasm, obesity
via ChEMBL · EBI
Research
5,488 papers- Cephalosporin-probenecid drug interactions.Clinical pharmacokinetics · 1993
- Clinical pharmacokinetics of probenecid.Clinical pharmacokinetics · 1981
- The history and future of probenecid.Cardiovascular toxicology · 2012
- Probenecid-clofibrate interaction.Clinical pharmacology and therapeutics · 1981
- Probenecid: an emerging tool for neuroprotection.CNS & neurological disorders drug targets · 2013
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 285.103479
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₃H₁₉NO₄S
- canonical SMILES
- CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
- defined daily dose
- 1
- World Health Organisation international non-proprietary name
- probenecid
- melting point
- 199
- Commons category
- Probenecid
via Wikidata · CC0