Structure via PubChem · Public domain (PubChem)
Probenecid
Sign in to saveAlso known as Probalan®, p-(Dipropylsulfamoyl)benzoic acid, 4-((Dipropylamino)sulfonyl)benzoic acid, Probenecid Acid, Probenecide, 4-(Di-N-propylsulfamoyl)benzoesaeure, Probenecida
farmaco
Key facts
- Drug.verifiedrevid
- 459812016
- Drug.IUPAC_name
- 4-(dipropylsulfamoyl)benzoic acid
- Drug.image
- Probenecid.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Probenecid ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Probalan
- Drug.MedlinePlus
- a682395
- Drug.legal_status
- Rx only
- Drug.routes_of_administration
- By mouth
- Drug.protein_bound
- 75-95%
- Drug.elimination_half life
- 2-6 hours (dose: 0.5-1 g)
- Drug.excretion
- kidney (77-88%)
- Drug.CAS_number
- 57-66-9
- Drug.ATC_prefix
- M04
- Drug.ATC_suffix
- AB01
via Wikipedia infobox
Chemical data
- Formula
- C13H19NO4S
- Molecular weight
- 285.36 g/mol
- IUPAC name
- 4-(dipropylsulfamoyl)benzoic acid
- SMILES
- CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
- InChIKey
- DBABZHXKTCFAPX-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 83.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1951
- Admin. routes
- oral
- Indications
- gout, infection, neoplasm, obesity
via ChEMBL · EBI
Research
5,488 papers- Cephalosporin-probenecid drug interactions.Clinical pharmacokinetics · 1993
- Clinical pharmacokinetics of probenecid.Clinical pharmacokinetics · 1981
- The history and future of probenecid.Cardiovascular toxicology · 2012
- Probenecid-clofibrate interaction.Clinical pharmacology and therapeutics · 1981
- Probenecid: an emerging tool for neuroprotection.CNS & neurological disorders drug targets · 2013
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 285.103479
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₃H₁₉NO₄S
- canonical SMILES
- CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
- defined daily dose
- 1
- World Health Organisation international non-proprietary name
- probenecid
- melting point
- 199
- Commons category
- Probenecid
via Wikidata · CC0
Article · Italiano
Probenecid è un agente ad attività uricosurica (che incrementa cioè l'eliminazione urinaria di acido urico, abbassandone conseguentemente la concentrazione nel sangue), ottenuta grazie al blocco del trasporto tubulare renale. In diversi paesi del mondo viene venduto con il nome commerciale di Probalan, Benuryl o Benemid. Come farmaco è usato essenzialmente nella terapia dell'iperuricemia e della gotta.
Abstract from DBpedia / Wikipedia · CC BY-SA