File:Propofol.svg · Wikimedia Commons · See Wikimedia Commons
Propofol
Sign in to saveAlso known as 2,6-diisopropylphenol, ICI 35868, 2,6-bis(1-methylethyl)phenol, 2,6-di(propan-2-yl)phenol
chemische Verbindung, Arzneistoff, schnell wirkendes Narkosemittel
OverviewAI-generated
Propofol is a chemical compound with the formula C₁₂H₁₈O. Its IUPAC name is 2,6-di(propan-2-yl)phenol. The substance has a mass of 178.136 and a density of 0.955. Physical properties include a melting point of 18, a boiling point of 247, and a refractive index of 1.5140.
Chemical analysis indicates that propofol has an xlogp of 3.8 and a tpsa of 20.2. It contains one hydrogen bond donor and one hydrogen bond acceptor, with a charge of 0. The canonical SMILES representation is CC(C)C1=C(C(=CC=C1)C(C)C)O.
The compound is referenced by 1,153 other encyclopedia articles. A search for propofol in PubMed yields a count of 29528.
Synthesized by Vinony from 22 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 456484691
- Drug.image
- Propofol.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Propofol ball-and-stick model from xtal 2014.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of propofol
- Drug.tradename
- Diprivan, others
- Drug.DailyMedID
- Propofol
- Drug.pregnancy_AU
- C
- Drug.addiction_liability
- Moderate
- Drug.dependency_liability
- Physical: Very high Psychological: no data
- Drug.routes_of_administration
- Intravenous
- Drug.class
- GABAA receptor agonist;sedative;general anesthetic
- Drug.ATC_prefix
- N01
- Drug.ATC_suffix
- AX10
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
via Wikipedia infobox
Chemical data
- Formula
- C12H18O
- Molecular weight
- 178.27 g/mol
- IUPAC name
- 2,6-di(propan-2-yl)phenol
- SMILES
- CC(C)C1=C(C(=CC=C1)C(C)C)O
- InChIKey
- OLBCVFGFOZPWHH-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 20.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1989
- Admin. routes
- parenteral
- Indications
- leukemia, morbid obesity, pain, hypertension
via ChEMBL · EBI
Research
29,528 papers- Propofol: Milk of Amnesia.Cell · 2018
- Propofol infusion syndrome: a structured literature review and analysis of published case reports.British journal of anaesthesia · 2019
- Propofol: A Medication That Changed Pediatric Anesthesia Practice.Paediatric anaesthesia · 2025
- Propofol.Dimensions of critical care nursing : DCCN · 2001
- [Propofol: use, toxicology and assay features].Sudebno-meditsinskaia ekspertiza · 2022
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 178.136
- Manufacturer
- Pfizer
- Has use
- medication
Show 10 more facts
- Commons category
- Propofol
- chemical formula
- C₁₂H₁₈O
- medical condition treated
- anaesthesia
- canonical SMILES
- CC(C)C1=C(C(=CC=C1)C(C)C)O
- World Health Organisation international non-proprietary name
- propofolum
- melting point
- 18
- boiling point
- 247
- density
- 0.955
- refractive index
- 1.5140
- subject has role
- essential medicine
via Wikidata · CC0
Article · Deutsch
Propofol ist ein Arzneistoff aus der Gruppe der Narkotika, der aufgrund seines raschen Wirkungseintritts und seiner kurzen Plasmahalbwertszeit und relativ geringen Kumulation als gut steuerbar gilt. Propofol ist ein geringfügig wasserlösliches Phenolderivat. In den handelsüblichen Präparaten ist Propofol in einer milchig-weißen Emulsion gelöst. Es wirkt als allosterischer Modulator an pentameren Ionenkanälen wie GABAA-Rezeptoren und nikotinischen Acetylcholinrezeptoren. Es wurde 1977 durch Brian Kay und George Rolly erstmals in einer klinischen Studie getestet und 2016 in die Reihe der essentiellen Arzneimittel der WHO aufgenommen. John B. Glen erhielt für die Entwicklung 2018 den Lasker~DeBakey Clinical Medical Research Award.
Abstract from DBpedia / Wikipedia · CC BY-SA