psilocybin
Sign in to savePsilocybin, also known as '4-phosphoryloxy-N,N-dimethyltryptamine (4-PO-DMT'), is a naturally occurring tryptamine alkaloid and investigational drug found in more than 200 species of mushrooms, with hallucinogenic and serotonergic effects. Effects include euphoria, changes in perception, a distorted sense of time, and perceived spiritual experiences. It can also cause adverse reactions such as nausea and panic attacks.
AI overview
Psilocybin is a naturally occurring compound found in certain mushrooms that produces hallucinogenic effects, including altered perception, euphoria, and changes in how people experience time. It is being investigated as a potential medicine and can cause both positive experiences and adverse reactions like nausea and panic attacks.
AI-generated from the Wikipedia summary — may contain errors.
Key facts
- Drug.synonyms
- Psilocybine; Psilocibin; Psylocybin; Psilotsibin; Psilocin phosphate; Psilocin phosphate ester; O-Phosphorylpsilocin; O-Phosphoryl-4-hydroxy-N,N-dimethyltryptamine; 4-Phosphoryloxy-N,N-dimethyltryptamine; 4-PO-DMT; COMP360; COMP-360; CY-39; CY39; PSOP
- Drug.IUPAC_name
- [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
- Drug.C
- 12
- Drug.H
- 17
- Drug.N
- 2
- Drug.O
- 4
- Drug.P
- 1
- Drug.SMILES
- CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O
- Drug.StdInChI
- 1S/C12H17N2O4P/c1-14(2)7-6-9-8-13-10-4-3-5-11(12(9)10)18-19(15,16)17/h3-5,8,13H,6-7H2,1-2H3,(H2,15,16,17)
- Drug.StdInChIKey
- QVDSEJDULKLHCG-UHFFFAOYSA-N
- Drug.melting_point
- 220-228
Article
49 sectionsContents
- Uses
- Medical
- Dosing
- Available forms
- Effects
- Psychological and perceptual effects
- Set and setting and moderating factors
- Theory of mind network and default mode network
- Group perceptions
- Cultural significance and "mystical" experiences
- Physical effects
- Onset and duration
- Contraindications
- Adverse effects
- Psychiatric adverse effects
- Tolerance and dependence
- Long-term effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Miscellaneous
- Chemistry
- Physical properties
- Laboratory synthesis
- Analytical methods
- Structural analogues
- Natural occurrence
- Biosynthesis
- History
- Early
- Modern
- Society and culture
- Usage
- Legal status
- Advocacy for tolerance
- Research
- Psychiatric and other disorders
- Depression
- Obsessive–compulsive disorder
- See also
- Notes
- References
- External links
Psilocybin, also known as '4-phosphoryloxy-N,N-dimethyltryptamine (4-PO-DMT'), is a naturally occurring tryptamine alkaloid and investigational drug found in more than 200 species of mushrooms, with hallucinogenic and serotonergic effects. Effects include euphoria, changes in perception, a distorted sense of time, and perceived spiritual experiences. It can also cause adverse reactions such as nausea and panic attacks.
Psilocybin is a prodrug of psilocin. That is, the compound itself is biologically inactive but quickly converted by the body to psilocin. Psilocybin is transformed into psilocin by dephosphorylation mediated via phosphatase enzymes. Psilocin is chemically related to the neurotransmitter serotonin and acts as a non-selective agonist of the serotonin receptors. Activation of one serotonin receptor, the serotonin 5-HT2A receptor, is specifically responsible for the hallucinogenic effects of psilocin and other serotonergic psychedelics. Psilocybin is usually taken orally. By this route, its onset is about 20 to 50 minutes, peak effects occur in about 1 to 2 hours, and its duration is about 4 to 6 hours.