PTPN14

Also known as PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14, PTPD2

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.

In the Vinony graph

Within Vinony's link graph, PTPN14 is referenced by 87 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 1.

Its subject is documented across 5 Wikipedia language editions.

Gene data

PTPN14

Name: protein tyrosine phosphatase non-receptor type 14
Type: protein-coding
Position: 214,348,700–214,552,449 (−)
Aliases: CATLPH, PEZ, PTP36, PTPD2
Ensembl: ENSG00000152104
RefSeq RNA: NM_005401.5, XM_017001941.2, XM_024448759.2, XM_047426367.1, XM_047426370.1
RefSeq protein: NP_005392.2, XP_016857430.1, XP_024304527.1, XP_047282323.1, XP_047282326.1

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010].