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PWZ-029
Sign in to savePWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys, It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.
Chemical data
- Formula
- C14H14ClN3O2
- Molecular weight
- 291.73 g/mol
- IUPAC name
- 8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
- SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C=C(C=C3)Cl)COC
- InChIKey
- FXIDXTIMKAEBGY-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 47.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 291.077454
Show 3 more facts
- chemical formula
- C₁₄H₁₄ClN₃O₂
- canonical SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C=C(C=C3)Cl)COC
- subject has role
- nootropic
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
PWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys, It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.
==See also== GABAA receptor negative allosteric modulator GABAA receptor § Ligands GL-II-73
Excerpted from Wikipedia’s “PWZ-029” article, available under the CC BY-SA 4.0 licence.