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Structure via PubChem · Public domain (PubChem)
PWZ-029
Sign in to savePWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys, It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.
In the Vinony graph
Vinony's link graph records 365 inbound references to PWZ-029, and connects out to GABAA receptor, picrotoxin and tetrahydrodeoxycorticosterone.
Vinony files it under Chemical pages without DrugBank identifier, Chloroarenes and Drugboxes which contain changes to verified fields.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C14H14ClN3O2
- Molecular weight
- 291.73 g/mol
- IUPAC name
- 8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
- SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C=C(C=C3)Cl)COC
- InChIKey
- FXIDXTIMKAEBGY-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 47.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 291.077454
Show 3 more facts
- chemical formula
- C₁₄H₁₄ClN₃O₂
- canonical SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C=C(C=C3)Cl)COC
- subject has role
- nootropic
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
PWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys, It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.
==See also== GABAA receptor negative allosteric modulator GABAA receptor § Ligands GL-II-73
Excerpted from Wikipedia’s “PWZ-029” article, available under the CC BY-SA 4.0 licence.