Gene data
RELA- Name
- RELA proto-oncogene, NF-kB subunit
- Type
- protein-coding
- Position
- 65,653,599–65,663,138 (−)
- Aliases
- AIF3BL3, CMCU, NFKB3, p65
- Ensembl
- ENSG00000173039
- RefSeq RNA
- NM_001145138.2, NM_001243984.2, NM_001243985.2, NM_001404657.1, NM_001404658.1
- RefSeq protein
- NP_001138610.1, NP_001230913.1, NP_001230914.1, NP_001391586.1, NP_001391587.1
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
transcription cis-regulatory region bindingRNA polymerase II transcription regulatory region sequence-specific DNA bindingRNA polymerase II transcription regulatory region sequence-specific DNA bindingRNA polymerase II transcription regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA binding
Pathways
MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)NF-kappa B signaling pathway - Homo sapiens (human)HIF-1 signaling pathway - Homo sapiens (human)Sphingolipid signaling pathway - Homo sapiens (human)Mitophagy - animal - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
RELA proto-oncogene, NF-kB subunit
- Symbol
- RELA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,653,599-65,663,138
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein RELA PDB 1bft.png
Show 8 more facts
- HomoloGene ID
- 32064
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5970
- genomic end
- 65663090
- genomic start
- 65653599
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.1
- expressed in
- right coronary artery
Sources (3)
via Wikidata · CC0