RGS9
Sign in to saveAlso known as PERRS, RGS9L, regulator of G-protein signaling 9, regulator of G protein signaling 9
Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM]
Gene data
RGS9- Name
- regulator of G protein signaling 9
- Type
- protein-coding
- Position
- 65,100,812–65,227,703 (+)
- Aliases
- PERRS, PERRS1, RGS9L
- Ensembl
- ENSG00000108370
- RefSeq RNA
- NM_001081955.3, NM_001165933.2, NM_003835.4
- RefSeq protein
- NP_001075424.1, NP_001159405.1, NP_003826.2
This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
regulator of G protein signaling 9
- Symbol
- RGS9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:65,100,812-65,227,703
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM]
There are two splice isoforms of RGS9 with quite different properties and patterns of expression. RGS9-1 is mainly found in the eye and is involved in regulation of phototransduction in rod and cone cells of the retina; genetic mutations in RGS9-1 cause the eye disease bradyopsia. RGS9-2 is found in the brain, and regulates dopamine and opioid signaling in the basal ganglia.
Excerpted from Wikipedia’s “RGS9” article, available under the CC BY-SA 4.0 licence.