RRM2B
Sign in to saveAlso known as MTDPS8A, MTDPS8B, P53R2, ribonucleotide reductase regulatory TP53 inducible subunit M2B, RCDFRD
Ribonucleotide-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene. The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.
Gene data
RRM2B- Name
- ribonucleotide reductase regulatory TP53 inducible subunit M2B
- Type
- protein-coding
- Position
- 102,204,502–102,239,382 (−)
- Aliases
- MTDPS8A, MTDPS8B, P53R2, RCDFRD
- Ensembl
- ENSG00000048392
- RefSeq RNA
- NM_001172477.1, NM_001172478.2, NM_015713.5
- RefSeq protein
- NP_001165948.1, NP_001165949.1, NP_056528.2
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein RRM2B PDB 2VUX.png
Show 5 more facts
- HomoloGene ID
- 56723
- exact match
- identifiers.org/ncbigene/50484
- genomic end
- 102238961
- genomic start
- 103216730
- cytogenetic location
- 8q22.3
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Article
5 sectionsContents
- Function
- Interactions
- Clinical relevance
- References
- Further reading
Ribonucleotide-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene. The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.
==Function== RRM2B codes for one of two versions of the R2 subunit of ribonucleotide reductase, which generates nucleotide precursors required for DNA replication by reducing ribonucleoside diphosphates to deoxyribonucloside diphosphates. The version of R2 encoded by RRM2B is induced by p53, and is required for normal DNA repair and mtDNA synthesis in non-proliferating cells. The other form of R2 is expressed only in dividing cells.