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(RS)-dobutamine

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(RS)-dobutamine

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Also known as DL-dobutamine, 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine, rac-dobutamine, racemic-dobutamine, 4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol, (+-)-4-(2-{[3-(p-hydroxyphenyl)-1-methylpropyl]amino}ethyl)pyrocatechol, dobutamine

Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure. It may also be used in certain types of cardiac stress tests. It is given by IV only, as an injection into a vein or intraosseous as a continuous infusion. The amount of medication needs to be adjusted to the desired effect. Onset of effects is generally seen within 2 minutes. It has a half-life of two minutes. This drug is generally only administered short term, although it may be used for longer periods to relieve symptoms of heart failure in patients a

Chemical data

Formula
C18H23NO3
Molecular weight
301.4 g/mol
IUPAC name
4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol
SMILES
CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
InChIKey
JRWZLRBJNMZMFE-UHFFFAOYSA-N
XLogP
3.4
Polar surface area
72.7 Ų
H-bond donors
4
H-bond acceptors
4
Formal charge
0

via PubChem

~5 min read

Encyclopedic overview

6 sections
Contents
  • Medical uses
  • Adverse effects
  • Pharmacology
  • History
  • References
  • External links

{{Drugbox | verifiedrevid = 459442789 | IUPAC_name = (RS)-4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol | image = Dobutamine.svg | image_class = skin-invert-image | width = 250 | chirality = Racemic mixture

| tradename = Dobutrex, Inotrex, others | Drugs.com = | MedlinePlus = a682861 | DailyMedID = Dobutamine | pregnancy_AU = B2 | pregnancy_AU_comment = | pregnancy_US = B | pregnancy_US_comment = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Intravenous, intraosseous | class = β1-agonist

Excerpted from Wikipedia’s “(RS)-dobutamine” article, available under the CC BY-SA 4.0 licence.