Structure via PubChem · Public domain (PubChem)
(RS)-pimobendan
Sign in to saveAlso known as DL-pimobendan, pimobendan, pimobendane
Pimobendan (INN, or pimobendane), sold under the brand name Vetmedin among others, is a veterinary medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilator effects.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 408556559
- Drug.image
- Pimobendan skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Pimobendan.jpg
- Drug.chirality
- Racemic mixture
- Drug.tradename
- Vetmedin, others
- Drug.DailyMedID
- Pimobendan
- Drug.routes_of_administration
- By mouth
- Drug.class
- Calcium sensitizer
- Drug.ATCvet
- yes
- Drug.ATC_prefix
- C01
- Drug.ATC_suffix
- CE90
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- 60 to 65%
via Wikipedia infobox
Chemical data
- Formula
- C19H18N4O2
- Molecular weight
- 334.4 g/mol
- IUPAC name
- 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
- SMILES
- CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC
- InChIKey
- GLBJJMFZWDBELO-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 79.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
7 papers- Preliminary Bioequivalence of an Oral Pimobendan Solution Formulation with Reference Solution Formulation in Beagle Dogs.Veterinary sciences · 2022
- Pimobendan controlled release guar gum printlets: Tailoring drug doses for personalised veterinary medicines.International journal of pharmaceutics · 2024
- Pimobendan B from powder diffraction data.Acta crystallographica. Section E, Structure reports online · 2013
- Impact of a combination of pimobendan, furosemide, and enalapril on heart rate variability in naturally occurring, symptomatic, myxomatous mitral valve degeneration dogs.BMC veterinary research · 2023
- From prototype to veterinary patient: a pharmacokinetic clinical trial of 3D-printed pimobendan tablets in beagle dogs.Drug delivery and translational research · 2026
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 334.143
Show 5 more facts
- chemical formula
- C₁₉H₁₈N₄O₂
- canonical SMILES
- CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC
- World Health Organisation international non-proprietary name
- pimobendan
- subject has role
- phosphodiesterase inhibitor
- Commons category
- Pimobendan
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Mechanism of action
- Pharmacokinetics
- Combinations
- Synthesis
- References
- Further reading
Pimobendan (INN, or pimobendane), sold under the brand name Vetmedin among others, is a veterinary medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilator effects.
Pimobendan is used in the management of heart failure in dogs, most commonly caused by myxomatous mitral valve disease (also previously known as endocardiosis), or dilated cardiomyopathy. Research has shown that as a monotherapy, pimobendan increases survival time and improves quality of life in canine patients with congestive heart failure secondary to mitral valve disease when compared with benazepril, an ACE inhibitor. Under the brand name Acardi, it is available for human use in Japan. It is available as a generic medication.
Excerpted from Wikipedia’s “(RS)-pimobendan” article, available under the CC BY-SA 4.0 licence.