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Structure via PubChem · Public domain (PubChem)
tracazolate
Sign in to saveAlso known as ICI-136,753, ICI-136753
Tracazolate (ICI-136,753) is an anxiolytic drug which is used in scientific research. It is a pyrazolopyridine derivative, most closely related to pyrazolopyrimidine drugs such as zaleplon, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures.
Chemical data
- Formula
- C16H24N4O2
- Molecular weight
- 304.39 g/mol
- IUPAC name
- ethyl 4-(butylamino)-1-ethyl-6-methylpyrazolo[3,4-b]pyridine-5-carboxylate
- SMILES
- CCCCNC1=C2C=NN(C2=NC(=C1C(=O)OCC)C)CC
- InChIKey
- PCTRYMLLRKWXGF-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 69 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 304.189926
Show 3 more facts
- chemical formula
- C₁₆H₂₄N₄O₂
- canonical SMILES
- CCCCNC1=C2C=NN(C2=NC(=C1C(=O)OCC)C)CC
- Commons category
- Tracazolate
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Tracazolate (ICI-136,753) is an anxiolytic drug which is used in scientific research. It is a pyrazolopyridine derivative, most closely related to pyrazolopyrimidine drugs such as zaleplon, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures.
Tracazolate has primarily anxiolytic and anticonvulsant effects, with sedative and muscle relaxant effects only appearing at higher doses. It has a unique receptor binding profile involving allosteric modulation of several GABAA receptor subtypes, being selective for GABAA receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.
Excerpted from Wikipedia’s “tracazolate” article, available under the CC BY-SA 4.0 licence.